Yes it's not uncommon.
The MB SL has a V6 (in europe), a V8 (NA), V8 (SC), V12 tt, V12 tt (larger).
Porsche 911 has 4 different engines. Entry level to supercar
BMW I6, V8, and V12 in the same car.
Infiniti V6, V8 in same car
Cadillac V6, V8 in same car
Honda, Toyota, Nissan, Ford...