You might get more replies if you specify what you are trying to achieve. If you want a sub, the best location is in the passenger footwell. If you want some back fill, that's another issue.
Personally, I use the center channel (running off the head unit) for back fill. I have a switch that turns it on or off. I have upgraded the door speakers and have a toolbox sub in the passenger footwell plus amps to run all that stuff.
The amount of backfill volume coming from the head unit and the little BOSE speaker in the center channel is enough. I turn it off when driving alone, but when a passenger is present, I use the center channel. It seems to help with balance of sound that is blocked when a passenger is in the car.
That being said, the center channel does screw with the imaging from an audiophile perspective. Plenty of people on this forum would poo-poo the idea of additional speakers in the NSX. Personally, I find the center channel worth having - especially when you can flip a switch to turn it off.
Cheers!
Shaun