More specifically, we drove from Sulphur Springs. (Most people have no clue where that is so I use Texarkana as a reference.)
We ended in Fort Knox... just 20 minutes off 65 once you hit Elizabethtown which is about 30 minutes from Louisville.
In a Honda Odyssey, traveling no faster than 75mph at any given time, with 4 kids in tow, (to give you an idea of how often we have to stop because SOMEONE always has to "go") :biggrin: , it tooks us about 13 hours. This includes 2 stops for sit down meals plus 3-4 stops for restroom breaks and gas.
If you can average about 70mph (barring any bladder issues or female passengers) you should be able to easily do it in 10 hours.