This has been hashed over many times if you’d like to do some searching, but I’ll offer a little insight as I see it.
For the most part I agree with Black&Tan, and although I won’t flame 01balcks4 I will suggest that his answer is too generic, somewhat careless, and probably does not reflect personal experience with forced induction NSX engines.
First off, we need to be more specific about what constitutes medium or high boost. Thus far, few if any NSXs are running the levels seen in some engines. But they are often generating more power per CC than others running higher boost, so perhaps we should speak in terms of power per unit displacement. In any case, for our purposes I would consider 1-6 psi as low, 7-12 as medium, and 13 up as high.
As noted, some of the “pioneers” of medium to high boost NSX systems leaned the hard way that both the stock cast pistons and the open-deck block design are potential weak points. That should certainly not be a surprise since cast pistons were recognized as vulnerable decades before the NSX, and other open-deck engines have had problems with cylinder “walk” and warping when turbos were added. (most notably 300ZX non-turbo and Porsche 944 engines).
The stock open-deck/cylinder liner issue is probably related more to power generated per stroke (torque) than peak HP. In other words, a centrifugal SC making 500HP typically creates far less average torque throughout the power band than does a turbo with the same peak HP, and therefore may be less prone to this problem.
Under ideal conditions the stock pistons will cope with medium output levels and may even survive into the higher range. However, “ideal conditions” means very accurate and consistent control of fuel, timing, intake temps, exhaust temps, spotless combustion chambers, good plugs, coils, etc. Unfortunately it is unrealistic to expect that all those things will be or remain “ideal” at all times, and that’s why you need to build in a certain margin for error, or “headroom”. The most important thing to remember about forced induction is that it magnifies the bad with the good, making headroom all the more important. Your stock NSX could be lugged up a hill on a hot day running cheap fuel and a faulty knock sensor, pinging all the way, and suffer no apparent damage. (sounds like every Pinto ever made) A low boost CTSC or turbo that leans out a bit as revs climb might rattle a bit from time to time or cause unhealthy combustion chamber temps, but they don’t generally crush ringlands. A few may have suffered valve issues, but overall they are pretty tolerant. However, the same engine running 12 psi can kill piston in seconds, and at 18psi it can happen in the blink of an eye. Forget knock sensors, at high boost levels they probably aren’t fast enough to stop the train once it starts at those levels. With forged pistons you buy time, and time is headroom. So just because someone manages to generate 500 RWHP on stock internals doesn’t mean it’s “safe”. Impressive, yes, but probably not the best gamble IMO.