Nitrous Oxide is a proven safe and effective anesthetic gas. Quoting these potential effects, especially in the context of your actual exposure in an automotive setting is again misleading, especially in the original discussion of 2-nitropropane.
Pulmonary Hypertension: N2O does increase Pulmonary vascular resistance in patients who already have elevated Pulmonary artery pressures, but not in infants. Normal adults given anesthetic amounts of N2O (50-66%) will have an increase during the anesthetic.
Intestinal distension: N2O has a much higher blood:gas partition coefficient (34x) than Nitrogen. As a result, N2O will enter gas-containing body cavities ("gas bubble") much faster than the Nitrogen in those cavities can be removed by circulation. In cases of bowel distension or worse, bowel obstruction, this can worsen the situation. Actual rupture is far less of a concern than bowel ischemia and or necrosis due to high intraluminal pressures. These effects are dependent on the amount and duration of N2O exposure. Basically, you will need to continously breath 50% N2O for nearly 2 hours to double the size of the air in your gut.
Bone Marrow suppression: Studies have shown that prolonged exposure to N2O (done on dentists/ occupational exposure) can produce anemia, possibly via inhibition/suppression of B12 metabolism or DNA biosynthesis.
Best Regards,
Danny
Pulmonary Hypertension: N2O does increase Pulmonary vascular resistance in patients who already have elevated Pulmonary artery pressures, but not in infants. Normal adults given anesthetic amounts of N2O (50-66%) will have an increase during the anesthetic.
Intestinal distension: N2O has a much higher blood:gas partition coefficient (34x) than Nitrogen. As a result, N2O will enter gas-containing body cavities ("gas bubble") much faster than the Nitrogen in those cavities can be removed by circulation. In cases of bowel distension or worse, bowel obstruction, this can worsen the situation. Actual rupture is far less of a concern than bowel ischemia and or necrosis due to high intraluminal pressures. These effects are dependent on the amount and duration of N2O exposure. Basically, you will need to continously breath 50% N2O for nearly 2 hours to double the size of the air in your gut.
Bone Marrow suppression: Studies have shown that prolonged exposure to N2O (done on dentists/ occupational exposure) can produce anemia, possibly via inhibition/suppression of B12 metabolism or DNA biosynthesis.
Best Regards,
Danny