Bluelink2 operates in two modes: as a receiver, music is transmitted wirelessly via bluetooth (from an iPhone, Android device etc.) to the Bluelink, which in turn outputs an analog signal that is used as an input to your sound system. As a transmitter, it does just the opposite: it accepts an analog input and transmits it via bluetooth to whatever device you wish, bluetooth headphones for example. I use it only as a receiver.
The Bluelink2 does not support handsfree calling, only music streaming. Actually this is one of the reasons I'm using it (the other being it powers up and links automatically). The vehicle I'm using it in (not the NSX) already has a separate handsfree (Johnson Controls Blueconnect) which works really well, and my wife is used to it, so I needed something that only supported streaming.
If you need handsfree also, the only game in town for the NSX is the Grom. It has several configurations so you can set it up the way you like. The USB feature is really cool, it essentially replaces the CD changer with a USB stick. I decided to forgo the wired approach in favor of bluetooth-only because I prefer not to physically attach the phone every time I get in the car, and I dislike wires dangling around my interior, especially one as tight as the NSX. If I need to charge the phone I'll hook it up the the lighter adapter, otherwise it stays in my pocket or the coin tray (which, happily, holds my iPhone case perfectly).
See also this thread:
http://www.nsxprime.com/forum/showthread.php?t=121560